Which of the following medications can lead to hypertension when combined?

When considering the potential for hypertension resulting from medication interactions, it's essential to understand the pharmacological effects of the combinations involved. The combination of magnesium sulfate and hydralazine is particularly noteworthy in this context.

Magnesium sulfate is often used in various medical conditions, including pre-eclampsia, where it helps to prevent seizures. However, it is also known to have a relaxing effect on muscles and blood vessels, primarily through its role as a vasodilator. On the other hand, hydralazine is an antihypertensive medication that acts by dilating blood vessels, thereby lowering blood pressure. When both magnesium sulfate and hydralazine are used together, there can be a balance disruption in the body's regulatory mechanisms leading to paradoxical effects. In certain situations, particularly if the doses are not managed carefully or if the patient has specific underlying health conditions, this combination can contribute to elevated blood pressure rather than mitigating it.

In contrast, other medication combinations provided in the options either do not typically lead to hypertension or may even lower blood pressure. Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), can potentially cause fluid retention and elevated blood pressure when used long-term, but in this case, the combination with aspirin is not typically