What psychological effect does decreased serum or plasma protein have on the elderly?

Decreased serum or plasma protein levels in the elderly can significantly alter the distribution of drugs within the body. Proteins in the blood, such as albumin, play a crucial role in binding medications. When protein levels are low, there are fewer binding sites available for drugs, leading to increased free (unbound) drug concentrations in the bloodstream. This can enhance the drug's effects and potentially increase the risk of toxicity, as unbound drugs are more active and can exert stronger pharmacological effects.

In the elderly, who often experience changes in body composition and organ function, the impact of altered protein levels can be even more pronounced, affecting drug metabolism and elimination. This understanding is essential for effectively managing pharmacotherapy in older patients, as it can guide dosage adjustments to ensure safety and efficacy in treatment.